FER FERRITIN Magnetic Solid Phase Chemiluminescence Immunoassay
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FER FERRITIN Magnetic Solid Phase Chemiluminescence Immunoassay

The kit has been designed for the quantitative determination of Ferritin (FER) in human serum.
The method can be used for samples over the range of 1.0~1000.0 ng/mL.
The test has to be performed Taizhou ZECEN Biotech Co., Ltd. model CIA 600, CIA 600Plus, CIA
1200, CIA 1200M, CIA 1800, CIA 2800 and POClia 8, POClia minus, POClia plus, POClia auto
automatic chemiluminescence analyzer.
Shenzhen IncreCare Biotech Co., Ltd. model Shine i1900、Shine i2900 automatic chemiluminescence analyzer.
  • FER


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FER is a kind of soluble tissue protein to store iron in the body. Normal serum contains a small  amount of FER. Serum iron levels decreased in acute anemia and pregnancy period, and elevated  in acute and chronic liver damage and liver cancer. In recent years an acidic isoferritin is also  found from liver cancer, called carcinoembryonic isoferritin, which may contribute to early  diagnosis 

FER concentration is very low in the blood. Iron content is about 1% in normal plasma. Serum  Ferritin is in balance with the body storage, but it will vary with the amount of stored iron ion. In  the earliest period of anemia and iron deficiency, Ferritin concentration in plasma decreased. This  is much earlier than the changes of hemoglobin concentration, red blood cell size and total iron  binding capacity. Therefore, serum ferritin can be used as an early indicator of iron deficiency.  Meanwhile, large number of chronic conditions can lead to elevated serum Ferritin levels,  including chronic infection, chronic inflammatory diseases such as rheumatoid arthritis, heart  disease and other malignancies, especially lymphoma, leukemia, breast cancer and neuroblastoma,  etc. Patients with these disorders always are accompanied by iron deficiency, but serum Ferritin  level is normal. In patients with hepatitis or toxic liver damage, Ferritin levels elevated because  Ferritin is released from damaged liver cells. In addition, Ferritin also rises for hemochromatosis and hemosiderosis. 

FER, though not specific, but only elevated in liver cancer and pancreas cancer, and did not elevate  in other gastrointestinal tumors such as esophageal cancer, stomach cancer, colorectal cancer. For  Liver cancer patient, if therapeutically effective, Ferritin decreased, while for the deterioration and  recurrence it will elevate. If it continued to increase, it indicates the prognosis is poor. Therefore,  it can be used as one means of monitoring the efficacy, especially in patients who tested negative  for FER. 

FER is mainly used in dynamic monitoring with cancer and assists diagnosis of disease  progression or therapeutic effect, but its concentration is not directly correlated with tumor size,  growth, malignancy and grade/stage. For some benign diseases such as aplastic anemia,  sideroblastic anemia, chronic hemolytic anemia, liver disease, myocardial infarction, acute  infections, lead poisoning and anemia caused by a lack of vitamin B6 and so on, FER also rise. It  cannot be used for cancer screening in the general population, especially early and definite  diagnosis.

Zecen Biotech CO., LTD. founded in 2011, is a leading Chinese diagnostics manufacturer specializing in in-vitro diagnostics devices and reagents.
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