Herpes Simplex Virus 2 IgM(HSV-2 IgM) TORCH Reagents for IVD CLIA Automatic Immunoassay Analyzer in Human Serum Samples

TORCH Herpes Simplex Virus 2 IgM(HSV-2 IgM) Reagents for Automatic Immunoassay Analyzer in Human Serum Samples from China manufacturer - ZECEN Bio

A study by the German Institute of Medical Virology on the immune response of HSV-1 structural proteins, non-structural proteins and the body's IgM and IgG found that during the acute infection stage of HSV, IgM mainly recognizes structural proteins, early viral proteins and early polypeptides; In the early stages, the HSV glycoprotein is not recognized (see Figure 3). This is consistent with the transcriptional expression process of the HSV genome, proving that the main antigens that cause IgM immune responses during HSV infection are early proteins, early polypeptides (i.e. early proteins), structural proteins, etc.; it can be seen that natural antigens are the detection The best choice for HSV-IgM.

Herpes simplex virus type 2 (HSV-2) is the cause of most genital herpes. Now, HSV-1 has become an important cause and represents even about 30% of genital herpes in some countries. So, study related to genital herpes should consider both HSV-1 and HSV-2.

Though serum HSV-1 and 2 IgM in STDs are less diagnostic, they help to see the iceberg part of the infection among the population concerned in recent scenario or in another words, it provides recent infective burden.

Since most genital HSV infections are unrecognized and undiagnosed, serum HSV-1 and 2 IgM helps to see the iceberg part of the infection among the population concerned. But when serum HSV-1 and 2 IgM come positive in any of the patients having STD, it may be sero-conversion of primary infection or reactivation. In the community, when HSV transmissibility increased by sexual route, case of primary infection and reactivation of herpes virus also increased. This phenomenon directly leads the level of serum HSV-1 and 2 IgM in STD patients – both herpetic and non-herpetic groups are also going to be increased. So, serum HSV-1 and 2 IgM can be used for periodically screening in STD patient to know the trend, transmissibility and load of HSV.