Tissue-type Plasminogen Activator-inhibitor Complex ( T-PAIC)

The t-PAIC (Tissue-type Plasminogen Activator-inhibitor Complex ) Assay Kit is an in vitro diagnostic reagent intended for the quantitative determination of t-PAIC in human plasma. t-PAIC is a complex formed by the binding of tissue plasminogen activator (t-PA), released upon vascular endothelial cell injury, and plasminogen activator inhibitor-1 (PAI-1). Since the concentration of t-PA in blood is only one-fifth that of PAI-1, virtually all t-PA in circulation is bound to PAI-1; therefore, the appearance of t-PAIC can early reflect the occurrence of fibrinolysis inhibition.

As a novel molecular marker reflecting both vascular endothelial injury and fibrinolytic system inhibition, t-PAIC can detect pathophysiological changes in the pre-thrombotic state earlier than conventional coagulation tests, providing clinicians with precise diagnostic and therapeutic guidance.

Intended Use：

This kit is intended for the in vitro quantitative determination of tissue plasminogen activator-inhibitor complex (t-PAIC) in human plasma.