Tumor marker Squamous Cell Carcinoma Antigen(SCC) chemiluminescence detection kit in closed analyzer
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Tumor marker Squamous Cell Carcinoma Antigen(SCC) chemiluminescence detection kit in closed analyzer

SCC is mainly used in dynamic monitoring with cancer and assists diagnosis of disease progression or therapeutic effect, but its concentration is not directly correlated with tumor size, growth, malignancy and grade/stage. For some benign diseases such as hepatitis, cirrhosis, pneumonia, and tuberculosis and so on, SCC also rise. It cannot be used for cancer screening in the general population, especially early and definite diagnosis.
  • SCC

  • Zecen

  • DR1019

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SCC is a group of glycoprotein of serine/cysteine protease inhibitor family, with molecular weight of 45,000 Daltons. SCC was originally isolated from squamous cell carcinoma by Kato and etc. It is composed of at least 10 different subunits of isoelectric points.

In the diagnosis of cervical cancer: SCC sensitivity of primary cervical squamous cell carcinoma was 44% -69%; of recurrent cancer was 67% to 100% , and specificity is 90% -96%; its serum level is related with tumor development, extent of violations and metastasis. After radical operation of cervical cancer, SCC decreased significantly; SCC can prompt early recurrence, for 50% of patients, elevated level of SCC is 2-5 months earlier than the clinical diagnosis, which can be applied as an independent risk factor. SCC assists the diagnosis of lung squamous cell carcinoma.

It is related with SCC tumor progression. Combined with CA125, CYFRA21-1 and CEA, it will improve the diagnostic sensitivity of lung cancer. For ESCC prediction, SCC increased with progression of the disease. For patients with advanced disease, the sensitivity can be up to 73%.

Combined with CYFRA21-1, it can improve the detection sensitivity. In addition, SCC also plays an important role in other cancers (such as: head and neck cancer, vulvar cancer, bladder cancer,

anal cancer, skin cancer, etc.)

Actors affecting the detectability of SCCA in serum

Tumor size and volume (more tumor cells result in a larger amount of SCCA);

Invasiveness of the primary tumor or recurrence;

Lymph node metastasis (LNM) (secreted SCCA from tumor cells in lymph nodes is easily detected in the bloodstream);

Distant metastasis (circulating tumor cells enable easy detection of secreted SCCA in blood tests);

Impairment of immunosurveillance.



Zecen Biotech CO., LTD. founded in 2011, is a leading Chinese diagnostics manufacturer specializing in in-vitro diagnostics devices and reagents.
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