CA242
ZECEN
DR1054
| Quantity: | |
|---|---|
CA242 is a sialic acid-containing carbohydrate antigen attached to core proteins/lipids detected on the cell surface or in serum. Increased serum levels of CA242 have been used clinically as diagnostic biomarkers for pancreatic, colorectal, and other cancers.
Since CA242 is overexpressed in malignant tumor tissues compared to that in normal tissues, it is believed that serum CA242 is a product of cancer cells.
Data showed that patients with pancreatic cancer, cervical cancer, and lymphoma had the highest median values of serum CA242, which were followed by esophagus cancer, colon cancer, ovarian cancer, type 2 diabetes mellitus, rectal cancer, coronary heart disease, breast cancer, diabetic nephropathy, acute myocardial infarction, and 15 other types of diseases compared to that of healthy controls.
In contrast, patients suffering from sequela of brain damage and anemia had statistically lower median values than healthy controls. Based on the –log10 p values, the increased serum CA242 levels could be used not only for diagnosis of pancreatic and other cancers, but also for diagnosis of type 2 diabetes mellitus and coronary heart disease, suggesting CA242 might be a systemic malfunction biomarker associated with cancers and other chronic diseases.
[INTENDED USE]
The kit has been designed for the quantitative determination of Carbohydrate Antigen 242 (CA242) in human serum.
The method can be used for samples over the range of 0-300IU/mL.
KIT COMPONENTS
Material Supplies
| Reagent Integral for 100 determinations | |
| Magnetic beads: magnetic beads complex binding with goat anti-FITC, buffer with BSA | 3.0ml |
| Calibrator Low: BSA Buffer | 0.3ml |
| Calibrator High: BSA Buffer | 0.3ml |
| CA242 Anti A+ Anti B: CA242 Antibody complex labeled FITC, containing buffer with BSA；CA242 Antibody complex labeled by AP, containing buffer with BSA | 6.0ml |
| All reagents are provided ready-to-use. | |
| Reagent Vials in kit box | |
Internal Quality Control: containing BSA buffer with different amount of CA242 Antigen (target value refer to Quality Control sheet) | 0.3ml |
Accessories Required But Not Provided
| CIA Substrate | REF: SR2001 |
| CIA System cleaning solution | REF: WR2001 |
| CIA Pileline cleaning solution | REF: WR2002 |
| Test item | CA242 |
| Specification | 50 Test/Box for CIA series |
| Component | Magnetic Beads |
| Calibrator Low | |
| Calibrator High | |
| TGAB Anti | |
| Control 1 | |
| Control 2 | |
| Accessories Required But Not Provided | Substrate |
| Washing solution | |
| Sample material | Serum |
| Sample volume | More than 200μL |
| Storage | 2-8℃ |
CA242 is a sialic acid-containing carbohydrate antigen attached to core proteins/lipids detected on the cell surface or in serum. Increased serum levels of CA242 have been used clinically as diagnostic biomarkers for pancreatic, colorectal, and other cancers.
Since CA242 is overexpressed in malignant tumor tissues compared to that in normal tissues, it is believed that serum CA242 is a product of cancer cells.
Data showed that patients with pancreatic cancer, cervical cancer, and lymphoma had the highest median values of serum CA242, which were followed by esophagus cancer, colon cancer, ovarian cancer, type 2 diabetes mellitus, rectal cancer, coronary heart disease, breast cancer, diabetic nephropathy, acute myocardial infarction, and 15 other types of diseases compared to that of healthy controls.
In contrast, patients suffering from sequela of brain damage and anemia had statistically lower median values than healthy controls. Based on the –log10 p values, the increased serum CA242 levels could be used not only for diagnosis of pancreatic and other cancers, but also for diagnosis of type 2 diabetes mellitus and coronary heart disease, suggesting CA242 might be a systemic malfunction biomarker associated with cancers and other chronic diseases.
[INTENDED USE]
The kit has been designed for the quantitative determination of Carbohydrate Antigen 242 (CA242) in human serum.
The method can be used for samples over the range of 0-300IU/mL.
KIT COMPONENTS
Material Supplies
| Reagent Integral for 100 determinations | |
| Magnetic beads: magnetic beads complex binding with goat anti-FITC, buffer with BSA | 3.0ml |
| Calibrator Low: BSA Buffer | 0.3ml |
| Calibrator High: BSA Buffer | 0.3ml |
| CA242 Anti A+ Anti B: CA242 Antibody complex labeled FITC, containing buffer with BSA；CA242 Antibody complex labeled by AP, containing buffer with BSA | 6.0ml |
| All reagents are provided ready-to-use. | |
| Reagent Vials in kit box | |
Internal Quality Control: containing BSA buffer with different amount of CA242 Antigen (target value refer to Quality Control sheet) | 0.3ml |
Accessories Required But Not Provided
| CIA Substrate | REF: SR2001 |
| CIA System cleaning solution | REF: WR2001 |
| CIA Pileline cleaning solution | REF: WR2002 |
| Test item | CA242 |
| Specification | 50 Test/Box for CIA series |
| Component | Magnetic Beads |
| Calibrator Low | |
| Calibrator High | |
| TGAB Anti | |
| Control 1 | |
| Control 2 | |
| Accessories Required But Not Provided | Substrate |
| Washing solution | |
| Sample material | Serum |
| Sample volume | More than 200μL |
| Storage | 2-8℃ |
