Cyclin D1 Protein ProteinAntibody Reagent(Immunohistochemistry)

The Cyclin D1 Protein Antibody Reagent (Immunohistochemistry) is an in vitro diagnostic (IVD) rabbit monoclonal antibody. It is intended for the qualitative detection of Cyclin D1 protein in formalin-fixed, paraffin-embedded (FFPE) human tissue sections using immunohistochemistry (IHC), with visualisation under light microscopy

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Product Description

Intended Use

The Cyclin D1 antibody is designed as an adjunctive diagnostic tool in pathology, with applications including:

1. Diagnosis and Differentiation of Mantle Cell Lymphoma (MCL)

IHC detection of Cyclin D1 is the most reliable immunohistochemical marker for the diagnosis of mantle cell lymphoma

Distinguishes mantle cell lymphomas (Cyclin D1 positive) from chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) and follicular lymphomas (Cyclin D1 negative)

This distinction is important because mantle cell lymphoma is a more aggressive neoplasm

2. Other B-Cell Lymphomas

Hairy cell leukaemia and plasma cell myeloma may weakly express Cyclin D1

3. Solid Tumours

Invasive breast cancer

Lung carcinoma and gastrointestinal neoplasms

4. Panel Application

Used in tandem with CD5, CD10, and CD23 as the most reliable immunohistochemical marker panel for mantle cell lymphoma。